Diurnal VarIatIon of Urinary “ hCG $ Subunit Core Fragment ” Production Evaluated in Patients
نویسندگان
چکیده
Fragment” Production Evaluated in Patients wfth Gynecological Neoplasms, Patrick Neven,”2 Ray K I/es,3 Paul G. Carter,’ John H. Shepherd,’ and Tim Chard3 [1 Gynecol. Once!. Unit, St. Bartholomew’s Hosp. and the Royal Marsden Hosp., London; 2A mene Kliniek St. Jan, Broekstraat 1000, Brussels, Belgium (address for correspondence), fax 32-2-219-86-96; 3Wilhianison Lab. for Molec. Oncol., St. Bartholomew’s Hosp., London]
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References 1. Cole LA, Schwartz PE, Wang Y. Urinary gonadotropin fragments (UGF) in cancers of the female reproductive system. I. Sensitivity and specificity, comparison with other markers. Gynecol Oncol 1988;31:82-90. 2. O’Connor JF, Schiatterer JP, Birken 5, Krichevsky A, Armstrong EG, McMahon D, et al. Development of highly sensitive immunoassays to measure human chorionic gonadotropin, its ...
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Human chorionic gonadotropin (hCG) is a highly specific tumor marker or trophoblastic neoplasms. Also in patients with non-trophoblastic tumors, hCG beta-related material has been frequently demonstrated in their urine. This material was termed beta-core fragment (beta-CF) since it is recognized by hCG beta-core directed antisera but not by hCG beta-carboxyterminal peptide (CTP) directed antise...
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In biological fluids, hCG and its free alpha- (hCG alpha) and beta-subunits (hCG beta), occur in multiple forms. These various forms differ at the molecular level primarily in glycosylation, but also differ in protein backbone modifications corresponding to the urinary low molecular weight fragment of the hCG beta-subunit (beta-core fragment). This microheterogeneous nature can be demonstrated ...
متن کاملEstablishment, value assignment, and characterization of new WHO reference reagents for six molecular forms of human chorionic gonadotropin.
BACKGROUND The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) established a Working Group to investigate means of improving the comparability of immunoassays for human chorionic gonadotropin (hCG), which was selected as a prototype glycoprotein analyte. The Working Group identified development of unambiguous nomenclature and production of new highly purified Inter...
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Intact human chorionic gonadotropin (hCG), hyperglycosylated hCG, and the free subunit are the forms of hCG produced by healthy tissues and tumors (1 ). Intact hCG is the predominant form in serum and plasma in pregnancy and trophoblastic disease, hyperglycosylated hCG in choriocarcinoma and testicular cancer, and the free subunit in nongestational malignancy. Proteases present in macrophages a...
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